Kraft AE, Bork NI, Subramanian H, Pavlaki N, Failla AV, Zobiak B, Conti M, Nikolaev VO. Phosphodiesterases 4B and 4D Differentially Regulate cAMP Signaling in Calcium Handling Microdomains of Mouse Hearts. Cells. 2024; 13(6):476. https://doi.org/10.3390/cells13060476 [PDF]

Willim J, Woike D, Greene D, Das S, Pfeifer K, Yuan W, Lindsey A, Itani O, Böhme AL, Tibbe D, Hönck HH, Hassani Nia F; Undiagnosed Diseases Network; Zech M, Brunet T, Faivre L, Sorlin A, Vitobello A, Smol T, Colson C, Baranano K, Schatz K, Bayat A, Schoch K, Spillmann R, Davis EE, Conboy E, Vetrini F, Platzer K, Neuser S, Gburek-Augustat J, Grace AN, Mitchell B, Stegmann A, Sinnema M, Meeks N, Saunders C, Cadieux-Dion M, Hoyer J, Van-Gils J, de Sainte-Agathe JM, Thompson ML, Bebin EM, Weisz-Hubshman M, Tabet AC, Verloes A, Levy J, Latypova X, Harder S, Silverman GA, Pak SC, Schedl T, Freson K, Mumford A, Turro E, Schlein C, Shashi V, Kreienkamp HJ. Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors. Nat Commun. 2024 Sep 10;15(1):7909.https://doi.org/10.1038/s41467-024-52095-x [PDF]

Wu G, Liu S, Hagenstein J, Alawi M, Hengel FE, Schaper M, Akyüz N, Liao Z, Wanner N, Tomas NM, Failla AV, Dierlamm J, Körbelin J, Lu S, Huber TB. Adeno-associated virus-based gene therapy treats inflammatory kidney disease in mice. J Clin Invest. 2024 Aug 15;134(17):e174722. https://doi.org/10.1172/JCI174722 [PDF]

Muhs S, Paraschiakos T, Schäfer P, Joosse SA, Windhorst S. Centrosomal Protein 55 Regulates Chromosomal Instability in Cancer Cells by Controlling Microtubule Dynamics. Cells. 2024 Aug 20;13(16):1382. https://doi.org/10.3390/cells13161382 [PDF]

Bär J, Fanutza T, Reimann CC, Seipold L, Grohe M, Bolter JR, Delfs F, Bucher M, Gee CE, Schweizer M, Saftig P, Mikhaylova M. Non-canonical function of ADAM10 in presynaptic plasticity. Cell Mol Life Sci. 2024 Aug 9;81(1):342. https://doi.org/10.1007/s00018-024-05327-8 [PDF]

Matschke J, Hartmann K, Pfefferle S, Wang Y, Valdes PA, Thies E, Schweizer M, Lütgehetmann M, Schmiedel S, Bernreuther C, Boyden ES, Glatzel M, Krasemann S. Inefficient tissue immune response against MPXV in an immunocompromised mpox patient. J Med Virol. 2024 Jul;96(7):e29811. https://doi.org/10.1002/jmv.29811 [PDF]

Goradia N, Werner S, Mullapudi E, Greimeier S, Bergmann L, Lang A, Mertens H, Węglarz A, Sander S, Chojnowski G, Wikman H, Ohlenschläger O, von Amsberg G, Pantel K, Wilmanns M. Master corepressor inactivation through multivalent SLiM-induced polymerization mediated by the oncogene suppressor RAI2. Nat Commun. 2024 Jun 19;15(1):5241. https://doi.org/10.1038/s41467-024-49488-3 [PDF]

Gui Y, Kim Y, Brenna S, Wilmes M, Zaghen G, Goulbourne CN, Kuchenbecker-Pöls L, Siebels B, Voß H, Gocke A, Schlüter H, Schweizer M, Altmeppen HC, Magnus T, Levy E, Puig B. Cystatin C loaded in brain-derived extracellular vesicles rescues synapses after ischemic insult in vitro and in vivo. Cell Mol Life Sci. 2024 May 20;81(1):224. https://doi.org/10.1007/s00018-024-05266-4 [PDF]

Cremer C, Schock F, Failla AV, Birk U. Modulated illumination microscopy: Application perspectives in nuclear nanostructure analysis. J Microsc. 2024 Apr 15. https://doi.org/10.1111/jmi.13297 [PDF] 

Wirth S, Schlößer A, Beiersdorfer A, Schweizer M, Woo MS, Friese MA, Lohr C, Grochowska KM. Astrocytic uptake of posttranslationally modified amyloid-β leads to endolysosomal system disruption and induction of pro-inflammatory signaling. Glia. 2024 Apr 17. https://doi.org/10.1002/glia.24539 [PDF]

Weißelberg S, Both A, Failla AV, Huang J, Linder S, Ohnezeit D, Bartsch P, Aepfelbacher M & Rohde H. Staphylococcus epidermidis alters macrophage polarization and phagocytic uptake by extracellular DNA release in vitro. npj Biofilms and Microbiomes 2024 10:1. https://doi.org/10.1038/s41522-024-00604-7 [PDF]

Carsten A, Failla AV, Aepfelbacher M. MINFLUX nanoscopy: Visualising biological matter at the nanoscale level. J Microsc. 2024 Apr 25. https://doi.org/10.1111/jmi.13306 [PDF]

Hassani Nia F, Woike D, Bento I, Niebling S, Tibbe D, Schulz K, Hirnet D , Skiba M, Hönck HH, Veith K, Günther C, Scholz T, Bierhals T, Driemeyer J, Bend R, Failla AV, Lohr C , Garcia Alai M, Kreienkamp HJ. Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans. Mol Psychiatry 29:1683-1697. https://doi.org/10.1038/s41380-022-01882-3 [PDF]

Ohnezeit D, Huang J, Westerkamp U, Brinschwitz V, Schmidt C, Günther T, Czech-Sioli M, Weißelberg S, Schlemeyer T, Nakel J, Mai J, Schreiner S, Schneider C, Friedel CC, Schwanke H, Brinkmann MM, Grundhoff A, Fischer N. (2024) Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling. PLoS Pathog 20(8): e1012426. https://doi.org/10.1371/journal.ppat.1012426 [PDF]

Konietzny A, Han Y, Popp Y, van Bommel B, Sharma A, Delagrange P, Arbez N, Moutin MJ, Peris L, Mikhaylova M. Efficient axonal transport of endolysosomes relies on the balanced ratio of microtubule tyrosination and detyrosination. J Cell Sci. 2024 Apr 15;137(8):jcs261737.https://doi.org/10.1242/jcs.261737 [PDF]

Bolamperti S, Saito H, Heerdmann S, Hesse E, Taipaleenmäki H. Tgif1-deficiency impairs cytoskeletal architecture in osteoblasts by activating PAK3 signaling. Elife. 2024 Apr 25;13:RP94265. https://doi.org/10.7554/eLife.94265 [PDF]

Sachs W, Blume L, Loreth D, Schebsdat L, Hatje F, Koehler S, Wedekind U, Sachs M, Zieliniski S, Brand J, Conze C, Florea BI, Heppner F, Krüger E, Rinschen MM, Kretz O, Thünauer R, Meyer-Schwesinger C. The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration. Nat Commun. 2024 Mar 1;15(1):1897. https://doi.org/10.1038/s41467-024-46273-0 [PDF]

Carlantoni C, Liekfeld LMH, Hemkemeyer SA, Schreier D, Saygi C, Kurelic R, Cardarelli S, Kalucka J, Schulte C, Beerens M, Mailer RK, Schäffer TE, Naro F, Pellegrini M, Nikolaev VO, Renné T, Frye M. The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling. Dev Cell. 2024 Feb 5;59(3):308-325.e11. https://doi.org/10.1016/j.devcel.2023.12.002 [PDF]

Danyukova T, Alimy AR, Velho RV, Yorgan TA, Di Lorenzo G, von Kroge S, Tidow H, Wiegert JS, Hermans-Borgmeyer I, Schinke T, Rolvien T, Pohl S. Mice heterozygous for an osteogenesis imperfecta-linked MBTPS2 variant display a compromised subchondral osteocyte lacunocanalicular network associated with abnormal articular cartilage. Bone. 2023 Dec;177:116927. https://doi.org/10.1016/j.bone.2023.116927 [PDF]

Klein M, Failla AV, Hermey G. Internally tagged Vps10p-domain receptors reveal uptake of the neurotrophin BDNF. J Biol Chem. 2023 Oct;299(10):105216. https://doi.org/10.1016/j.jbc.2023.105216 [PDF]

Zhang T, Wahib R, Zazara DE, Lücke J, Shiri AM, Kempski J, Zhao L, Agalioti T, Machicote AP, Giannou O, Belios I, Jia R, Zhang S, Tintelnot J, Seese H, Grass JK, Mercanoglu B, Stern L, Scognamiglio P, Fard-Aghaie M, Seeger P, Wakker J, Kemper M, Brunswig B, Duprée A, Lykoudis PM, Pikouli A, Giorgakis E, Stringa P, Lausada N, Gentilini MV, Gondolesi GE, Bachmann K, Busch P, Grotelüschen R, Maroulis IC, Arck PC, Nakano R, Thomson AW, Ghadban T, Tachezy M, Melling N, Achilles EG, Puelles VG, Nickel F, Hackert T, Mann O, Izbicki JR, Li J, Gagliani N, Huber S, Giannou AD. CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis. Oncoimmunology. 2023 Oct 20;12(1):2269634. https://doi.org/10.1080/2162402X.2023.2269634 [PDF]

Hey S, Wiesner C, Barcelona B, Linder S. KIF16B drives MT1-MMP recycling in macrophages and promotes co-invasion of cancer cells. Life Sci Alliance. 2023 Sep 11;6(11):e202302158. https://doi.org/10.26508/lsa.202302158 [PDF]

Holling T, Brylka L, Scholz T, Bierhals T, Herget T, Meinecke P, Schinke T, Oheim R, Kutsche K. TMCO3, a Putative K⁺ :Proton Antiporter at the Golgi Apparatus, Is Important for Longitudinal Growth in Mice and Humans. J Bone Miner Res. 2023 Sep;38(9):1334-1349. https://doi.org/10.1002/jbmr.4827 [PDF]

Schöenfeld L, Appl B, Pagerols-Raluy L, Heuer A, Reinshagen K, Boettcher M. Immunofluorescence Imaging of Neutrophil Extracellular Traps in Human and Mouse Tissues. J Vis Exp. 2023 Aug 18;(198). doi: 10.3791/65272. Erratum in: J Vis Exp. 2023 Sep 29;(199). https://doi.org/10.3791/65272

Grochowska KM, Sperveslage M, Raman R, Failla AV, Głów D, Schulze C, Laprell L, Fehse B, Kreutz MR. Chaperone-mediated autophagy in neuronal dendrites utilizes activity-dependent lysosomal exocytosis for protein disposal. Cell Rep. 2023 Aug 29;42(8):112998. doi: http://doi.org/10.1016/j.celrep.2023.112998 [PDF]

Andres-Alonso M, Borgmeyer M, Mirzapourdelavar H, Lormann J, Klein K, Schweizer M, Hoffmeister-Ullerich S, Oelschlegel AM, Dityatev A, Kreutz MR. Golgi satellites are essential for polysialylation of NCAM and expression of LTP at distal synapses. Cell Rep. 2023 Jul 25;42(7):112692. https://doi.org/10.1016/j.celrep.2023.112692 [PDF]

Albertini S, Martuscelli L, Borgogna C, Virdi S, Indenbirken D, Lo Cigno I, Griffante G, Calati F, Boldorini R, Fischer N, Gariglio M. Cancer-Associated Fibroblasts Exert Proangiogenic Activity in Merkel Cell Carcinoma. J Invest Dermatol. 2023 Jun;143(6):965-976.e15. https://doi.org/10.1016/j.jid.2022.12.006 [PDF]

Weiß M, Hernandez LC, Gil Montoya DC, Löhndorf A, Krüger A, Kopdag M, Uebler L, Landwehr M, Nawrocki M, Huber S, Woelk LM, Werner R, Failla AV, Flügel A, Dupont G, Guse AH, Diercks BP. Adhesion to laminin-1 and collagen IV induces the formation of Ca2+ microdomains that sensitize mouse T cells for activation. Sci Signal. 2023 Jun 20;16(790):eabn9405. http://doi.org/10.1126/scisignal.abn9405 [PDF]

Dragoun Kolibová S, Wölfel EM, Hemmatian H, Milovanovic P, Mushumba H, Wulff B, Neidhardt M, Püschel K, Failla AV, Vlug A, Schlaefer A, Ondruschka B, Amling M, Hofbauer LC, Rauner M, Busse B, Jähn-Rickert K. Osteocyte apoptosis and cellular micropetrosis signify skeletal aging in type 1 diabetes. Acta Biomater. 2023 May;162:254-265. http://doi.org/10.1016/j.actbio.2023.02.037 [PDF]

Englert H, Göbel J, Khong D, Omidi M, Wolska N, Konrath S, Frye M, Mailer RK, Beerens M, Gerwers JC, Preston RJS, Odeberg J, Butler LM, Maas C, Stavrou EX, Fuchs TA, Renné T. Targeting NETs using dual-active DNase1 variants. Front Immunol. 2023 May 23;14:1181761. https://doi.org/10.3389/fimmu.2023.1181761 [PDF]

Hecher L, Harms FL, Lisfeld J, Alawi M, Denecke J, Kutsche K. INPP4A-related genetic and phenotypic spectrum and functional relevance of subcellular targeting of INPP4A isoforms. Neurogenetics. 2023 Apr;24(2):79-93. https://doi.org/10.1007/s10048-023-00709-9 [PDF]

Kylies D, Zimmermann M, Haas F, Schwerk M, Kuehl M, Brehler M, Czogalla J, Hernandez LC, Konczalla L, Okabayashi Y, Menzel J, Edenhofer I, Mezher S, Aypek H, Dumoulin B, Wu H, Hofmann S, Kretz O, Wanner N, Tomas NM, Krasemann S, Glatzel M, Kuppe C, Kramann R, Banjanin B, Schneider RK, Urbschat C, Arck P, Gagliani N, van Zandvoort M, Wiech T, Grahammer F, Sáez PJ, Wong MN, Bonn S, Huber TB, Puelles VG. Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of pathology specimens. Nat Nanotechnol. 2023 Apr;18(4):336-342.https://doi.org/10.1038/s41565-023-01328-z [PDF]

Nauth T, Bazgir F, Voß H, Brandenstein LI, Mosaddeghzadeh N, Rickassel V, Deden S, Gorzelanny C, Schlüter H, Ahmadian MR, Rosenberger G. Cutaneous manifestations in Costello syndrome: HRAS p.Gly12Ser affects RIN1-mediated integrin trafficking in immortalized epidermal keratinocytes. Hum Mol Genet. 2023 Jan 6;32(2):304-318. https://doi.org/10.1093/hmg/ddac188 [PDF]

Stern L, Boehme LF, Goetz MR, Nitschke C, Giannou A, Zhang T, Güngör C, Reeh M, Izbicki JR, Fliegert R, Hausen A, Giese N, Hackert T, Niv MY, Heinrich S, Gaida MM, Ghadban T. Potential role of the bitter taste receptor T2R14 in the prolonged survival and enhanced chemoresponsiveness induced by apigenin. Int J Oncol. 2023 Jan;62(1):6. https://doi.org/10.3892/ijo.2022.5454 [PDF]

Carsten A, Rudolph M, Weihs T, Schmidt R, Jansen I, Wurm CA, Diepold A, Failla AV, Wolters M, Aepfelbacher M. MINFLUX imaging of a bacterial molecular machine at nanometer resolution. Methods Appl Fluoresc. 2022 Dec 13;11(1). http://doi.org/10.1088/2050-6120/aca88010.1088/2050-6120/aca880 [PDF]

Taipaleenmäki H, Saito H, Schröder S, Maeda M, Mettler R, Ring M, Rollmann E, Gasser A, Haasper C, Gehrke T, Weiss A, Grimm SK, Hesse E. Antagonizing microRNA-19a/b augments PTH anabolic action and restores bone mass in osteoporosis in mice. EMBO Mol Med. 2022 Nov 8;14(11):e13617.https://doi.org/10.15252/emmm.202013617 [PDF]

Hassani Nia F, Woike, D, Bento I, Niebling S, Tibbe D, Schulz K, Hirnet D, Skiba M, Hönck HH, Veith K, Günther C, Scholz T, Bierhals T, Driemeyer J, Bend R, Failla AV, Lohr C, Alai MG, Kreienkamp HJ. Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans. Mol Psychiatry. 2022 Nov 30. https://doi.org/10.1038/s41380-022-01882-3 [PDF]

Stamm J, Weißelberg S, Both A, Failla AV, Nordholt G, Büttner H, Linder S, Aepfelbacher M, Rohde H. Development of an artificial synovial fluid useful for studying Staphylococcus epidermidis joint infections. Front. Cell. Infect. Microbiol. 2022 Jul 22; 1070. http://doi.org/10.3389/fcimb.2022.948151 . [PDF]

Hausrat TJ, Janiesch PC, Breiden P, Lutz D, Hoffmeister-Ullerich S, Hermans-Borgmeyer I, Failla AV, Kneussel M. Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice. Nat Commun. 2022 Jul 20;13(1):4192. http://doi.org/10.1038/s41467-022-31776-5 . [PDF]

D'Acunto E, Gianfrancesco L, Serangeli I, D'Orsi M, Sabato V, Guadagno NA, Bhosale G, Caristi S, Failla AV, De Jaco A, Cacci E, Duchen MR, Lupo G, Galliciotti G, Miranda E. Polymerogenic neuroserpin causes mitochondrial alterations and activates NFκB but not the UPR in a neuronal model of neurodegeneration FENIB. Cell Mol Life Sci. 2022 Jul 21;79(8):437. http://doi.org/10.1007/s00018-022-04463-3 . [PDF]

Holling T, Bhavani GS, von Elsner L, Shah H, Kausthubham N, Bhattacharyya SS, Shukla A, Mortier GR, Schinke T, Danyukova T, Pohl S, Kutsche K, Girisha KM. A homozygous hypomorphic BNIP1 variant causes an increase in autophagosomes and reduced autophagic flux and results in a spondylo-epiphyseal dysplasia. Hum Mutat. 2022 May;43(5):625-642. https://doi.org/10.1002/humu.24368 [PDF]

Holling T, Nampoothiri S, Tarhan B, Schneeberger PE, Vinayan KP, Yesodharan D, Roy AG, Radhakrishnan P, Alawi M, Rhodes L, Girisha KM, Kang PB, Kutsche K. Novel biallelic variants expand the SLC5A6-related phenotypic spectrum. Eur J Hum Genet. 2022 Apr;30(4):439-449. https://doi.org/10.1038/s41431-021-01033-2 [PDF]

Woike D, Wang E, Tibbe D, Hassani Nia F, Failla AV, Kibæk M, Overgård TM, Larsen MJ, Fagerberg CR, Barsukov I, Kreienkamp HJ. Mutations affecting the N-terminal domains of SHANK3 point to different pathomechanisms in neurodevelopmental disorders. Sci Rep. 2022 Jan 18;12(1):902. http://doi.org/10.1038/s41598-021-04723-5 [PDF]

Schneeberger PE, Nampoothiri S, Holling T, Yesodharan D, Alawi M, Knisely AS, Müller T, Plecko B, Janecke AR, Kutsche K. Biallelic variants in VPS50 cause a neurodevelopmental disorder with neonatal cholestasis. Brain. 2021 Nov 29;144(10):3036-3049. https://doi.org/10.1093/brain/awab206 [PDF]

Elazezy M, Schwentesius S, Stegat L, Wikman H, Werner S, Mansour WY, Failla AV, Peine S, Müller V, Thiery JP, Warkiani ME, Pantel K, Joosse SA. Emerging insights into keratin 16 expression during metastatic progression of breast cancer. Cancers (Basel). 2021 Jul 31;13(15):3869. https://doi.org/10.3390/cancers13153869 [PDF]

Hemmatian H, Conrad S, Furesi G, Mletzko K, Krug J, Failla AV, Kuhlmann JD, Rauner M, Busse B, Jähn-Rickert K. Reorganization of the osteocyte lacuno-canalicular network characteristics in tumor sites of an immunocompetent murine model of osteotropic cancers. Bone. 2021 Jun 23:116074. https://doi.org/10.1016/j.bone.2021.116074

Roggenkamp HG, Khansahib I, Hernandez C LC, Zhang Y, Lodygin D, Krüger A, Gu F, Möckl F, Löhndorf A, Wolters V, Woike D, Rosche A, Bauche A, Schetelig D, Werner R, Schlüter H, Failla AV, Meier C, Fliegert R, Walseth TF, Flügel A, Diercks BP, Guse AH. HN1L/JPT2: A signaling protein that connects NAADP generation to Ca2+ microdomain formation. Sci Signal. 2021 Mar 23;14(675):eabd5647. http://doi.org/10.1126/scisignal.abd5647 [PDF]

Both A, Huang J, Qi M, Lausmann C, Weißelberg S, Büttner H, Lezius S, Failla AV, Christner M, Stegger M, Gehrke T, Baig S, Citak M, Alawi M, Aepfelbacher M, Rohde H. Distinct clonal lineages and within-host diversification shape invasive Staphylococcus epidermidis populations. PLoS Pathog. 2021 Feb 5;17(2):e1009304. http://doi.org/10.1371/journal.ppat.1009304 [PDF]

von Palubitzki L, Wang Y, Hoffmann S, Vidal-Y-Sy S, Zobiak B, Failla AV, Schmage P, John A, Osorio-Madrazo A, Bauer AT, Schneider SW, Goycoolea FM, Gorzelanny C. Differences of the tumour cell glycocalyx affect binding of capsaicin-loaded chitosan nanocapsules. Sci Rep. 2020 Dec 31;10(1):22443. http://doi.org/10.1038/s41598-020-79882-y [PDF]

Maire CL, Mohme M, Bockmayr M, Fita KD, Riecken K, Börnigen D, Alawi M, Failla A, Kolbe K, Zapf S, Holz M, Neumann K, Dührsen L, Lange T, Fehse B, Westphal M, Lamszus K. Glioma escape signature and clonal development under immune pressure. J Clin Invest. 2020 Oct 1;130(10):5257-5271. http://doi.org/10.1172/JCI138760 [PDF]

[UKE Paper of the Month October 2020]
Brenna S, Altmeppen HC, Mohammadi B, Rissiek B, Schlink F, Ludewig P, Krisp C, Schlüter H, Failla AV, Schneider C, Glatzel M, Puig B, Magnus T. Characterization of brain-derived extracellular vesicles reveals changes in cellular origin after stroke and enrichment of the prion protein with a potential role in cellular uptake. J Extracell Vesicles. 2020 Aug 7;9(1):1809065. http://doi.org/10.1080/20013078.2020.1809065 [PDF]

Grunt M, Failla AV, Stevic I, Hillebrand T, Schwarzenbach H. A novel assay for exosomal and cell-free miRNA isolation and quantification, RNA Biol. 2020, http://doi.org/10.1080/15476286.2020.1721204 [PDF]

Yorgan TA, Sari H, Rolvien T, Windhorst S, Failla AV, Kornak U, Oheim R, Amling M, Schinke T. Mice lacking plastin-3 display a specific defect of cortical bone acquisition. Bone. 2020 Jan;130:115062. http://doi.org/10.1016/j.bone.2019.115062 [PDF]

Pelucchi S, Vandermeulen L, Pizzamiglio L, Aksan B, Yan J, Konietzny A, Bonomi E, Borroni B, Padovani A, Rust MB, Di Marino D, Mikhaylova M, Mauceri D, Antonucci F, Edefonti V, Gardoni F, Di Luca M, Marcello E. Cyclase-associated protein 2 dimerization regulates cofilin in synaptic plasticity and Alzheimer's disease. Brain Commun. 2020 Jun 26;2(2):fcaa086. https://doi.org/10.1093/braincomms/fcaa086 [PDF]

Liu HY, Koch C, Haller A, Joosse SA, Kumar R, Vellekoop MJ, Horst LJ, Keller L, Babayan A, Failla AV, Jensen J, Peine S, Keplinger F, Fuchs H, Pantel K, Hirtz M. Evaluation of Microfluidic Ceiling Designs for the Capture of Circulating Tumor Cells on a Microarray Platform. Adv Biosyst. 2020 Feb;4(2):e1900162. http://doi.org/10.1002/adbi.201900162 [PDF]

Sharaf A, Mensching L, Keller C, Rading S, Scheffold M, Palkowitsch L, Djogo N, Rezgaoui M, Kestler HA, Moepps B, Failla AV, Karsak M. Systematic Affinity Purification Coupled to Mass Spectrometry Identified p62 as Part of the Cannabinoid Receptor CB2 Interactome. Front Mol Neurosci. 2019 Sep 20;12:224. http://doi.org/10.3389/fnmol.2019.00224. eCollection 2019. [PDF]

Andres-Alonso M, Ammar MR, Butnaru I, Gomes GM, Acuña Sanhueza G, Raman R, Yuanxiang P, Borgmeyer M, Lopez-Rojas J, Raza SA, Brice N, Hausrat TJ, Macharadze T, Diaz-Gonzalez S, Carlton M, Failla AV, Stork O, Schweizer M, Gundelfinger ED, Kneussel M, Spilker C, Karpova A, Kreutz MR.
SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals. Nat Commun. 2019 Nov 29;10(1):5448. http://doi.org/10.1038/s41467-019-13224-z [PDF]

Herwig J, Skuza S, Sachs W, Sachs M, Failla AV, Rune G, Meyer TN, Fester L, Meyer-Schwesinger C.
Thrombospondin Type 1 Domain-Containing 7A Localizes to the Slit Diaphragm and Stabilizes Membrane Dynamics of Fully Differentiated Podocytes. J Am Soc Nephrol. 2019 May;30(5):824-839. http://doi.org/10.1681/ASN.2018090941 [PDF]
[Journal cover May 2019]

Zobiak B, Failla AV
Visualizing adhesion formation in cells by means of advanced spinning disk-total internal reflection fluorescence microscopy. J Vis Exp. 2019 Jan 21, (143):e58756. http://doi.org/10.3791/58756 [PDF]

Nauth T, Huschka F, Schweizer M, Bosse JB, Diepold A, Failla AV, Steffen A, Stradal T, Wolters M, Aepfelbacher M. Visualization of translocons in Yersinia type III protein secretion machines during host cell infection. PLoS Pathog. 2018 Dec 26;14(12):e1007527. http://doi.org/10.1371/journal.ppat.1007527. [PDF]

Diercks BP, Werner R, Weidemüller P, Czarniak F, Hernandez L, Lehmann C, Rosche A, Krüger A, Kaufmann U, Vaeth M, Failla AV, Zobiak B, Kandil FI, Schetelig D, Ruthenbeck A, Meier C, Lodygin D, Flügel A, Ren D, Wolf IM, Feske S, Guse AH. ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation. Sci. Signal 2018 Dec 18; 11(561) - http://doi.org/10.1126/scisignal.aat0358. [PDF]

Wang S, Brunne B, Zhao S, Chai X, Li J, Lau J, Failla AV, Zobiak B, Sibbe M, Westbrook GL, Lutz D, Frotscher M. Trajectory analysis unveils Reelin's role in the directed migration of granule cells in the dentate gyrus. J Neurosci. 2018 Jan 3; 38(1):137-148 - http://doi.org/10.1523/JNEUROSCI.0988-17.2017. [PDF]

Zobiak B, Failla AV. Advanced spinning disk-TIRF microscopy for faster imaging of the cell interior and the plasma membrane. J Microsc. 2018 Mar;269(3):282-290 - http://doi.org/10.1111/jmi.12626. [Article] [PDF]

Wackenhut F, Zobiak B, Meixner AJ, Failla AV. Tuning the fields focused by a high NA lens using spirally polarized beams. Chin Opt Lett. 2017; 15(3): 030013. http://doi.org/10.3788/COL201715.030013. [PDF]

Chai X, Zhao S, Fan L, Zhang W, Lu X, Shao H, Wang S, Song L, Failla AV, Zobiak B, Mannherz HG, Frotscher M. Reelin and cofilin cooperate during the migration of cortical neurons: A quantitative morphological analysis. Development. 2016 Mar 15;143(6):1029-40. Http://doi.org/10.1242/dev.134163. [PDF]

Mathes C, Brandner JM, Laue M, Raesch SS, Hansen S, Failla AV, Vidal S, Moll I, Schaefer UF, Lehr CM. Tight junctions form a barrier in porcine hair follicles. Eur J Cell Biol. 2015 Dec 29. pii: S0171-9335(15)30022-4. http://doi.org/10.1016/j.ejcb.2015.12.001. [PDF]

Wolters M, Zobiak B, Nauth T, Aepfelbacher M. Analysis of Yersinia enterocolitica Effector Translocation into Host Cells Using Beta-lactamase Effector Fusions. J Vis Exp. 2015 Oct 13;(104). http://doi.org/10.3791/53115. [PDF]

[UKE Paper of the Month July 2015]
Lin YN, Bhuwania R, Gromova K, Failla AV, Lange T, Riecken K, Linder S, Kneussel M, Izbicki JR, Windhorst S. Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion. Oncotarget. 2015 May 25. http://doi.org/10.18632/oncotarget.4094. [PDF]

Wackenhut F, Failla AV, Meixner AJ. Single gold nanorods as optical probes for spectral imaging. Anal Bioanal Chem. 2015 May;407(14):4029-34. Epub 2015 Apr 9. http://doi.org/10.1007/s00216-015-8642-1. [PDF]

Lin YN, Thata RN, Failla AV, Geissen M, Daum G, Windhorst S. Ex vivo aorta patch model for analysis of cellular adhesion. Tissue Cell. 2015 Mar 23. pii:S0040-8166(15)00022-1. http://doi.org/10.1016/j.tice.2015.03.004.

Decker R, Burdelski C, Zobiak M, Büttner H, Franke G, Christner M, Saß K, Zobiak B, Henke HA, Horswill AR, Bischoff M, Bur S, Hartmann T, Schaeffer CR, Fey PD, Rohde H. An 18 kDa Scaffold Protein Is Critical for Staphylococcus epidermidis Biofilm Formation. PLoS Pathog. 2015 Mar 23;11(3):e1004735. http://doi.org/10.1371/journal.ppat.1004735. eCollection 2015 Mar. [PDF] 

Ashour DJ, Pelka B, Jaaks P, Wundenberg T, Blechner C, Zobiak B, Failla AV, Windhorst S.
The catalytic domain of inositol-1,4,5-trisphosphate 3-kinase-a contributes to ITPKA-induced modulation of F-actin. Cytoskeleton (Hoboken). 2015 Jan 23. http://doi.org/10.1002/cm.21208. [PDF]

Kern AM, Zhang D, Brecht M, Chizhik AI, Failla AV, Wackenhut F, Meixner AJ. Enhanced single-molecule spectroscopy in highly confined optical fields: from λ/2-Fabry-Pérot resonators to plasmonic nano-antennas. Chem Soc Rev. 2014 Feb 21;43(4):1263-86. http://doi.org/10.1039/c3cs60357a. [PDF]

Kollmann K, Pestka JM, Kühn SC, Schöne E, Schweizer M, Karkmann K, Otomo T, Catala-Lehnen P, Failla AV, Marshall RP, Krause M, Santer R, Amling M, Braulke T, Schinke T. Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II. EMBO Mol Med. 2013 Dec;5(12):1871-86. http://doi.org/10.1002/emmm.201302979. [PDF]

Tilling T, Wladykowski E, Failla AV, Houdek P, Brandner JM, Moll I. Immunohistochemical analyses point to epidermal origin of human Merkel cells. Histochem Cell Biol. 2014 Apr;141(4):407-21. http://doi.org/10.1007/s00418-013-1168-8. [PDF]

Wackenhut F, Failla AV, and Meixner AJ. Multicolor Microscopy and Spectroscopy Reveals the Physics of the One-Photon Luminescence in Gold Nanorods. The Journal of Physical Chemistry C 2013 117 (34), 17870-17877. http://doi.org/10.1021/jp407353r. [PDF]

Wackenhut F, Failla AV, Meixner AJ. Sensing dielectric media on the nanoscale with freely oriented gold nanorods. Phys Chem Chem Phys. 2013 Apr 21;15(15):5407-14. http://doi.org/10.1039/c3cp43988g. [PDF]

Wackenhut F, Failla AV, Züchner T, Steiner M, Meixner AJ. Three-dimensional photoluminescence mapping and emission anisotropy of single gold nanorods. Applied Physics Letters, 100, 263102 (2012), http://dx.doi.org/10.1063/1.4729152. [PDF]

Jiao J, Wang X, Wackenhut F, Horneber A, Chen L, Failla AV, Meixner AJ, Zhang D. Polarization-dependent SERS at differently oriented single gold nanorods. Chemphyschem. 2012 Mar;13(4):952-8. http://doi.org/10.1002/cphc.201100718. [PDF]

Kulemzina I, Schumacher MR, Verma V, Reiter J, Metzler J, Failla AV, Lanz C, Sreedharan VT, Rätsch G, Ivanov D. Cohesin rings devoid of Scc3 and Pds5 maintain their stable association with the DNA. PLoS Genet. 2012;8(8):e1002856. http://doi.org/10.1371/journal.pgen.1002856. [PDF]

Correa de Sampaio P, Auslaender D, Krubasik D, Failla AV, Skepper JN, Murphy G, English WR.
A heterogeneous in vitro three dimensional model of tumour-stroma interactions regulating sprouting angiogenesis. PLoS One. 2012;7(2):e30753. http://doi.org/10.1371/journal.pone.0030753. [PDF]